HomeRoutes › Chicago to St Louis

Chicago St Louis

Lowest Price
$39
Highest Price
$97
Daily Trains
6

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Schedule

2026-04-01
DepartsArrivesDurationServicePriceTransfers
12:10am
Union Station
5:09am
Gateway Station - 430 S 15th St
4.98h
USLNC
#307
$47Direct
1:05am
Union Station
10:30am
Gateway Station - 430 S 15th St
9.42h
AMT
#59:8358
$971 stop
12:15pm
Union Station
5:01pm
Gateway Station - 430 S 15th St
4.77h
USLNC
#301
$39Direct
2:50pm
Union Station
7:51pm
Gateway Station - 430 S 15th St
5.02h
AMT
#319
$47Direct
7:10pm
Union Station
12:25am
Gateway Station - 430 S 15th St
5.25h
USTXE
#21
$81Direct
10:20pm
Union Station
3:23am
Gateway Station - 430 S 15th St
5.05h
USLNC
#305
$68Direct

Price History

Travel DateLowest PriceChecked
2026-04-01$392026-03-31
2026-03-31$392026-03-30
2026-03-30$562026-03-29

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About the Chicago to St Louis Train Route

Amtrak operates train service between Chicago and St Louis. Prices vary based on travel date, time of day, service class, and how far in advance you book. Booking early and traveling on weekdays typically yields the lowest fares.

We track prices daily across all available departure times so you can compare fares and find the best deal. Set a price alert above and we'll notify you the moment fares drop below your target.